Role of lubricin and boundary lubrication in the


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Galectin-3 Binds to Lubricin and Reinforces the ....

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...

Supramolecular synergy in the boundary lubrication of ....

Boundary lubrication measured in the SFB arises from dissipation at the slip plane between the intimately contacting boundary layers ... The role of lubricin in the mechanical behavior of ...

Friction force microscopy of lubricin and hyaluronic acid ....

Lubricin and hyaluronic acid (HA) are two constituents of synovial fluid thought to have a role in boundary lubrication. Boundary lubrication3 is accomplished by lubricants adsorbed or bonded to the apposing bearing surfaces and is operative where surfaces come into contact.4 It is one of the multiple

Regulation of lubricin for functional cartilage tissue ....

lubricin is verified to carry its responsibility for antag-onizing abnormal cellular adhesion and overgrowth. The fundamental role of lubricin is lubrication of boundary surface of cartilage [18]. Hence, transmuta-tion of lubricin metabolism would conspicuously influ-ence joint performance. In fact, patients who suffer

Proteoglycan 4 - Wikiped...

Function. Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

Proteoglycan 4 - Wikiped...

Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

The role of lubricin in the mechanical behavior of ....

Abstract Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Regulation of lubricin for functional cartilage tissue ....

Structure and functional role of lubricin. Lubricin, a product of the proteoglycan 4 (PRG4) gene, is highly expressed by synoviocytes and superficial zone chondrocytes [].Lubricin, generally known as a proteoglycan, is a glycoprotein that functions as a critical boundary lubricant for articular cartilage and normally isolated from synovial fluid [].

Molecular synergy in biolubrication: The role of cartilage ....

Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin ... M.L. Warman, G.D. JayRole of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc. Natl. Acad. Sci., 110 (15) (2013), pp. 5852-5857. Google Scholar.

Role of lubricin and boundary lubrication in the ....

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated ...

Conformational Mechanics, Adsorption, and Normal Force ....

Glycoproteins, such as lubricin, and hyaluronic acid (HA) play a prominent role in the boundary lubrication mechanism in diarthrodial joints. Although many studies have tried to elucidate the lubrication mechanisms of articular cartilage, the molecular details of how lubricin and HA interact with cartilage surfaces and mediate their interaction still remain poorly understood.

Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4 ....

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including boundary lubrication, friction lowering of apposed cartilage surfaces and prevention of synovial overgrowth. PRG4 is abundant in the synovial fluid (SF) and its levels are reduced in SF ...

NAVER Academic > Role of lubricin and boundary lubrication ....

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Author Kimberly A Waller, Ling X Zhang, Khaled A Elsaid, Braden C Fleming, Matthew L ...

Role of lubricin and boundary lubrication in the ....

Title: Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis: Authors: Waller, K. A.; Zhang, L. X.; Elsaid, K. A.; Fleming, B. C ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

The role of lubricin in the ... - PubMed Central (PM...

Therefore, lubricin provides a chondroprotective feature to synovial fluid that is distinct from the role lubricin plays at the cartilage surface as a boundary lubricant. Additional MPTM experiments, which involve reintroducing lubricin to HA in the presence of the synovial protein milieu, are needed.

Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4 ....

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including boundary lubrication, friction lowering of apposed cartilage surfaces and prevention of synovial overgrowth. PRG4 is abundant in the synovial fluid (SF) and its levels are reduced in SF ...

Transcription, Translation, and Function of Lubricin, a ....

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

PNAS揭示关节炎防治新方法 - 生物...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Osteoarthritis is a complex disease involving the mechanical breakdown of articular ...

Cartilage boundary lubrication synergism is ... - SpringerLi...

Background. Proteoglycan 4 (PRG4) and hyaluronan (HA) are key synovial fluid constituents that contribute synergistically to cartilage boundary lubrication; however, the effects of their concentrations as well as their structure, both of which can be altered in osteoarthritis, on this functional synergism are unknown.